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This measure is intended to support structured screening of differential diagnostic considerations. The Differential Diagnostic Questionnaire is a brief self-report tool used to organize symptom information that may be relevant to clinical formulation and diagnostic decision-making.
The questionnaire includes 20 items and typically takes about 4 minutes to complete. It may be used in clinical or research contexts to facilitate systematic review of reported concerns, support documentation, and guide follow-up assessment. The Differential Diagnostic Questionnaire is attributed to Robert L. Spitzer and Jean Endicott.